Interferometric monitoring of cytotoxic reactions on benign cells

During the last years, various approaches on an individualized drug therapy for benign cells have been researched. However, due to the complex topic an universal approach has not been found until this point. The main reason are the difference between malign and benign cells. Commonly, the effect of cytotoxic drugs on benign cells is mostly the same as to normal cells. However, the actual effect of cytotoxic agents on patient cells still can’t be predicted. In order to reduce unwanted side effects or unspecific drug reactions a test system for patients which allows to analyses the interaction between cytotoxic agents and the cells of the patient is need. Furthermore, this should also include an adequate measurement system which is capable to work in a natural environment and without any additional preparation of the cells. In terms of this work, a first proof of concept with cultured benign cells and different cytotoxic agents is presented while monitoring the obtained displacement using a modified electronic speckle pattern interferometry (ESPI).